LABORATORY OF DRUG SAFETY

Ludmila Petrovna Tochilkina
Head of the Laboratory.

In 1974, L. Tochilkina was graduated from the Volgograd State Medical School by specialty of therapeutic occupation. In 1978, she earned her Candidate for the work she did in pharmacology. Her academic degree is a senior research associate by specialty of toxicology. She has an international certificate of competence in good laboratory practice (Bio-Industry Initiative Project, USA)
Her professional interests include hygienic regulation of harmful substances for scenarios of their delayed exposure effects, better prophylaxis and treatment efficiency of acute and chronic poisonings by highly toxic chemicals, drug toxicology, specific toxicity types of remedies (reproduction toxicity and teratogenesis).
She is the author of more than 70 scientific papers.
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The Laboratory (former one of Experimental Toxicology) was founded in 1980 to solve scientifically applied tasks widespread in investigation. With staff of highly qualified experts and available modern equipment for using techniques in the fields such as physiology, biochemistry, microanatomy and microscopy, it has gained a vast amount of experience in toxicometry of delayed consequences from exposure to dangerous chemical mutants (mutagenic activity, reproduction toxicity and teratogenesis). This experience is successfully used in validation of the toxic agents' safe standards in industrial and environmental objects.

Considerable volume of investigation addresses the issues relating to experimental study of the pathogenesis of acute and chronic poisonings from lethal super toxicants, including those that are under destruction as chemical warfare agents. Considerable progress has been made towards the development or refinement of methods for prevention, management and provision of rehabilitation at a quickened pace. Emphasis is given to the prevention and a search for effective tools of pharmacological correction of delayed effects in cases of earlier intoxications, specifically, delayed neurotoxicity.

Criteria for effectiveness and safety of self-defense tools that contain tear gas and irritating substances have been demonstrated experimentally.

Research results are used as the basis for a number of standards and methodic instructions specifically, guidelines on the development of a new type of hygienic standards - Emergency Exposure Limits (EEL) for chemicals and other substances.

Pre-clinical studies of potential remedies (e.g., myorelaxants, adaptogenes, and etc.) represent an independent part of investigation. In the context of experimental strategies that have gone into the area of experimental toxicology since 2006, the Division has been rearranged into the Laboratory of Drug Safety.

There are promising avenues to explore in this relatively young research spectrum, and in these may be found solutions to the medical problems relating to remedies safety evaluation at pre-clinical stage of their study, prevention and treatment of delayed effects from acute poisonings.

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